Dalton Transactions (Print Edition) 2015-01-28

One-pot synthesis of an indole-substituted 7,8-dicarba-nido-dodecahydroundecaborate(-1).

W Neumann, R Frank, E Hey-Hawkins

文献索引：Dalton Trans. 44(4) , 1748-53, (2014)

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摘要

Carbaboranes are increasingly used as pharmacophores to replace phenyl substituents in established drug molecules. In contrast to traditional organic chemistry, elaborate procedures to introduce functionality frequently fail in the case of carbaboranes and their chemistry is often hampered by degradation of the cluster. Herein, the development of a one-pot synthesis of a water-soluble N-nido-dicarbaborato indole is presented, including a proposed mechanism for the reaction sequence. These studies provide useful synthetic tools for the conjugation of two important pharmacophores, indoles and carbaboranes.

相关化合物

  • 二氯甲烷
  • 四氢呋喃
  • 吲哚
  • 甲苯
  • 四甲基硅烷
  • 苯醌
  • 偶氮二甲酸二异丙酯
  • 偶氮二甲酰胺

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