British Journal of Cancer 2011-08-09

Mitochondrial recoupling: a novel therapeutic strategy for cancer?

G Baffy, Z Derdak, S C Robson

文献索引：Br. J. Cancer 105 , 469-474, (2011)

全文：HTML全文

摘要

Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of adenosine 5'-triphosphate, which is also a key determinant of glycolytic pathways. In addition, UCP suppress the generation of superoxide, a byproduct of mitochondrial electron transport and a major source of oxidative stress. The near ubiquitous UCP2 becomes highly abundant in some cancers and may advance metabolic reprogramming, further disrupt tumour suppression, and promote chemoresistance. Here we review current evidence to suggest that inhibition of mitochondrial uncoupling may eliminate these responses and reveal novel anti-cancer strategies.

相关化合物

  • 腺苷-5'-三磷酸二钠...
  • 腺苷5′-三磷酸镁盐

相关文献：

The novel protein kinase C epsilon isoform modulates acetylcholine release in the rat neuromuscular junction.

2015-01-01

[Mol. Brain 8 , 80, (2015)]

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout.

2015-06-01

[Arthritis Rheumatology 67 , 1646-56, (2015)]

A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography.

2014-09-19

[J. Chromatogr. A. 1360 , 240-7, (2014)]

Sequential phosphorylation analysis using dye-tethered peptides and microfluidic isoelectric focusing electrophoresis.

2015-11-15

[Biosens. Bioelectron. 73 , 93-9, (2015)]

A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.

2014-07-15

[J. Neurophysiol. 112(2) , 446-62, (2014)]

更多文献...