Journal of Pharmaceutical and Biomedical Analysis 2014-06-01

Water determination in active pharmaceutical ingredients using ionic liquid headspace gas chromatography and two different detection protocols.

Lillian A Frink, Choyce A Weatherly, Daniel W Armstrong

文献索引:J. Pharm. Biomed. Anal. 94 , 111-7, (2014)

全文:HTML全文

摘要

A rapid, accurate, precise and versatile analytical method was developed for the detection and quantification of water in solid active pharmaceutical ingredients (APIs). The headspace gas chromatography (HSGC) method utilized an ionic liquid (IL) based open tubular capillary GC column to increase sensitivity and ruggedness of this method. ILs are also utilized as the headspace solvent because of their low vapor pressure, unique physiochemical properties and high thermal stability. This method is not affected by side reactions and solubility problems which are common with Karl Fischer Titration (KFT) methods. Nor is it as limited as weight loss on drying approaches. The ability to use either/both modern thermal conductivity or barrier ion discharge GC detection provides flexibility, different dynamic ranges and sensitivity. The developed method also was shown to be broadly applicable. Copyright © 2014 Elsevier B.V. All rights reserved.


相关化合物

  • 利福平
  • 抗坏血酸
  • 布洛芬
  • DL-高半胱氨酸硫内...
  • 盐酸维拉帕米
  • DL-青霉胺
  • 杀鼠灵
  • D-青霉胺
  • 马来酸三甲丙咪嗪

相关文献:

Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy.

2014-12-01

[Tuberculosis (Edinb.) 94(6) , 701-7, (2015)]

Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.

2015-02-01

[PLoS Pathog. 11(2) , e1004645, (2015)]

Kinetics of recA and recX induction in drug-susceptible and MDR clinical strains of Mycobacterium tuberculosis.

2014-12-01

[J. Antimicrob. Chemother. 69(12) , 3199-202, (2014)]

A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.

2014-01-01

[PLoS ONE 9(4) , e93953, (2014)]

Desmethyl bosentan displays a similar in vitro interaction profile as bosentan.

2015-02-01

[Pulm. Pharmacol. Ther. 30 , 80-6, (2015)]

更多文献...