Bioorganic & Medicinal Chemistry 2011-12-01

Benzenepolycarboxylic acids with potential anti-hemorrhagic properties and structure–activity relationships

Hnin Thanda Aung, Toshiaki Nikai, Masatake Niwa, Yoshiaki Takaya

文献索引：Bioorg. Med. Chem. 19 , 7000-2, (2011)

全文：HTML全文

摘要

Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxylic acids and substituted benzoic acids against Protobothropsflavoviridis venom-induced hemorrhage. Pyromellitic acid (1,2,4,5-benzenetetracarboxylic acid) was found to be a potent inhibitor of hemorrhage, with an IC(50) value of 0.035 μM. In addition, most of the antihemorrhagic activity of compounds tested in this experiment showed good correlation to acidity.Copyright © 2011 Elsevier Ltd. All rights reserved.

相关化合物

  • 水杨酸
  • 3-羟基苯甲酸
  • 4-羟基苯甲酸
  • 苯甲酸
  • 咖啡酸
  • 对氯苯甲酸
  • 邻氯苯甲酸
  • 对苯二甲酸(PTA)
  • 反式,反式-1,3-丁二...
  • 苯六酸

相关文献：

Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid.

2015-10-01

[Neurobiol. Aging 36 , 2748-56, (2015)]

Graphene modified glassy carbon sensor for the determination of aspirin metabolites in human biological samples.

2015-10-01

[Talanta 143 , 328-34, (2015)]

Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles.

2015-01-01

[AAPS J. 17(1) , 256-67, (2015)]

Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity.

2015-01-01

[Int. J. Nanomedicine 10 , 229-43, (2015)]

Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms.

2015-01-01

[PLoS Negl. Trop. Dis. 9 , e0004173, (2015)]

更多文献...