Journal of medicinal and pharmaceutical chemistry 2009-11-12

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

Emeline L Maillet, Robert F Margolskee, Bedrich Mosinger

文献索引：J. Med. Chem. 52 , 6931-5, (2009)

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摘要

We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to glucose sensing. Thus, certain effects of fibrates in treating hyperlipidemia and type II diabetes may be via actions on T1R3. Likewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetected in studies on rodents.

相关化合物

  • 苯乙酸
  • 2,4-二氯苯氧乙酸
  • 1-萘乙酸
  • 2-甲基-4-氯戊氧基...
  • 4-氯苯氧乙酸
  • 3-吲哚丁酸
  • (R)-2-(2,4-二氯苯...
  • 2,4,6-三氯苯甲酸
  • 麦草畏
  • 2,4,5-涕丙酸

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