Molecular Diversity 2013-02-01

An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines.

Saeed Balalaie, Morteza Ashouriha, Frank Rominger, Hamid Reza Bijanzadeh

文献索引：Mol. Divers. 17(1) , 55-61, (2013)

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摘要

A three-component reaction of 3-formyl chromones, dialkyl acetylenedicarboxylate, and isocyanides in the presence of POCl(3) was used as a highly efficient and practical approach for the synthesis of 3-amino-5-chromenyl-butenolides. High yields and high bond forming efficiency, and simple operations are the advantages of this method. Graphical abstract.

相关化合物

  • 2(5H)-呋喃酮
  • γ-丁内酯
  • 2-丁炔二酸单钾盐
  • 丁炔二酸

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