Legal Medicine 2009-04-01

Studies on distribution of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry.

Miroslava Rohanova, Marie Balikova

文献索引:Leg. Med. (Tokyo.) 11 Suppl 1 , S429-30, (2009)

全文:HTML全文

摘要

para-Methoxymethamphetamine (PMMA) is an abused psychedelic compound with reports of several intoxications and deaths after ingestion. However, its pharmacokinetics based on a controlled study is unknown and only partial information on its biotransformation is available. Our experimental study was designed for the time disposition profile of PMMA and its metabolites para-methoxyamphetamine (PMA), para-hydroxymethamphetamine (OH-MAM) and para-hydroxyamphetamine (OH-AM) in blood and biological tissues in rats after the bolus subcutaneous dose 40 mg/kg using a validated GC-MS method. The experimental results ascertained could be useful for subsequent evaluation of PMMA psychotropic or neurotoxic effects and the diagnostic concern of intoxication.


相关化合物

  • 1-(4-甲氧基苯基)-N...

相关文献:

Determination of a newly encountered designer drug "p-methoxyethylamphetamine" and its metabolites in human urine and blood.

2008-05-02

[Forensic Sci. Int. 177(1) , 77-84, (2008)]

New designer drug p-methoxymethamphetamine: studies on its metabolism and toxicological detection in urine using gas chromatography-mass spectrometry.

2003-06-05

[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 789(1) , 27-41, (2003)]

Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) in rats after subcutaneous administration.

2009-05-02

[Toxicology 259(1-2) , 61-8, (2009)]

A re-examination of the mono-methoxy positional ring isomers of amphetamine, methamphetamine and phenyl-2-propanone.

2001-06-15

[Forensic Sci. Int. 119(2) , 168-94, (2001)]

A preliminary behavioral investigation of PMMA, the 4-methoxy analog of methamphetamine.

1988-09-01

[Pharmacol. Biochem. Behav. 31(1) , 9-13, (1988)]

更多文献...