European Journal of Medicinal Chemistry 2007-01-01

Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.

S Torres-Cartas, Y Martín-Biosca, R M Villanueva-Camañas, S Sagrado, M J Medina-Hernández

文献索引：Eur. J. Med. Chem. 42 , 1396-402, (2007)

全文：HTML全文

摘要

Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting mutagenicity of aromatic amines is demonstrated. A multiple linear regression (MLR) model based on BMC retention data is proposed and compared with other ones reported in bibliography. The proposed model present better or similar descriptive and predictive capability.

相关化合物

  • 1-氨基蒽
  • 对溴苯胺
  • 对氯苯胺
  • 2-氨基蒽
  • 1-氨基芘
  • 3,3'-二甲基联苯胺
  • 3,3'-二甲氧基联苯...
  • 4,4'-二氨基二苯甲...
  • 4-氨基二苯醚
  • 2-甲氧基-5-甲基苯...

相关文献：

Antitumor activity of acriflavine in lung adenocarcinoma cell line A549.

2014-11-01

[Anticancer Res. 34(11) , 6467-72, (2014)]

Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1.

2014-01-01

[PLoS ONE 9(5) , e96649, (2014)]

A high-throughput approach for identification of novel general anesthetics.

2009-01-01

[PLoS ONE 4(9) , e7150, (2009)]

Phenylalanine 35 and tyrosine 82 are involved in the uptake and release of ligand by porcine odorant-binding protein.

2009-08-01

[Biochim. Biophys. Acta 1794(8) , 1142-50, (2009)]

In vitro lipolysis by human pancreatic lipase is specifically abolished by its inactive forms.

2003-02-21

[Biochim. Biophys. Acta 1645(2) , 241-6, (2003)]

更多文献...