Journal of Pharmaceutical Sciences 1981-12-01

Convenient synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester.

A M Crider, R Grubb, K A Bachmann, A K Rawat

文献索引：J. Pharm. Sci. 70(12) , 1319-21, (1981)

全文：HTML全文

摘要

6-Nor-9,10-dihydrolysergic acid methyl ester (IV) was prepared by demethylation of 9,10-dihydrolysergic acid methyl ester (II) with 2,2,2-trichloroethyl chloroformate, followed by reduction of the intermediate carbamate (III) with zinc in acetic acid. The 6-ethyl-V and 6-n-propyl-VI derivatives were prepared by alkylation of IV with the appropriate halide. All of the ergoline derivatives were evaluated for stereotyped behavior in rats, with 6-nor-6-ethyl-9,10-dihydrolysergic acid methyl ester (V) being active but much less potent than apomorphine. Compound VI was evaluated for its effect on blood pressure; at a dose of 30 mg/kg ip, it significantly lowered, diastolic pressure in normotensive rats.

相关化合物

  • 氯甲酸-2,2,2-三氯...

相关文献：

Characterization of the designer drug bk-2C-B (2-amino-1-(bromo-dimethoxyphenyl)ethan-1-one) by gas chromatography/mass spectrometry without and with derivatization with 2,2,2-trichloroethyl chloroformate, liquid chromatography/high-resolution mass spectrometry, and nuclear magnetic resonance.

2015-07-15

[Rapid Commun. Mass Spectrom. 29 , 1196-204, (2015)]

Gas chromatography/mass spectrometry determination of amphetamine-related drugs and ephedrines in plasma, urine and hair samples after derivatization with 2,2,2-trichloroethyl chloroformate.

2005-01-01

[Rapid Commun. Mass Spectrom. 19(7) , 919-27, (2005)]

N-Demethylation of dextromethorphan.

1980-12-01

[J. Pharm. Sci. 69(12) , 1447-8, (1980)]

A simplified method for the gas chromatographic determination of pethidine and norpethidine after derivatization with trichloroethyl chloroformate.

[J. Chromatogr. A. 274 , 355-60, (1983)]

[An accident of chloroethyl chloroformate poisoning].

2011-01-01

[Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29(1) , 38, (2011)]

更多文献...