Natural product communications 2010-10-01

Antibacterial and antifungal screening of Centaurium pulchellum crude extracts and main secoiridoid compounds.

Branislav Siler, Danijela Misić, Jasmina Nestorović, Tijana Banjanac, Jasmina Glamoclija, Marina Soković, Ana Cirić

文献索引:Nat. Prod. Commun. 5(10) , 1525-30, (2010)

全文:HTML全文

摘要

The main principles of C. pulchellum (Sw.) Druce, secoiridoid glycosides, have been studied as potent bioactive compounds. Here we scored their content in extracts of ten populations of this species. Antibacterial and antifungal assays of the extracts and pure secoiridoid glycosides were performed against eight bacterial strains and five fungal species. Methanol extracts from both aerial parts and roots exhibited excellent antibacterial (0.05-0.2 mg mL(-1)) and very good antifungal (0.1-2 mg mL(-1)) activity. Pure secoiridoid glycosides isolated from these extracts demonstrated very strong antibacterial (0.01-0.04 mg mL(-1)) and especially antifungal (0.001-0.1 mg mL(-1)) activity.


相关化合物

  • 獐牙菜苦苷
  • 獐牙菜苷

相关文献:

Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics.

2011-06-01

[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(19) , 1653-8, (2011)]

Hypoglycemic activity of C-glycosyl flavonoid from Enicostemma hyssopifolium.

2011-04-01

[Pharm. Biol. 49(4) , 383-91, (2011)]

Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats.

2009-10-01

[J. Nat. Med. 63(4) , 437-42, (2009)]

Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch.

2010-01-01

[Biosci. Biotechnol. Biochem. 74(8) , 1583-90, (2010)]

Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils.

2012-02-01

[Phytother Res. 26(2) , 168-73, (2012)]

更多文献...