Molecules 2011-01-01

Knoevenagel reaction in [MMIm][MSO₄]: synthesis of coumarins.

Pedro Verdía, Francisco Santamarta, Emilia Tojo

文献索引：Molecules 16(6) , 4379-88, (2011)

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摘要

The ionic liquid 1,3-dimethylimidazolium methyl sulfate, [MMIm][MSO₄], together with a small amount of water (the amount taken up by the ionic liquid upon exposure to air), acts efficiently as both solvent and catalyst of the Knoevenagel condensation reactions of malononitrile with 4-substituted benzaldehydes, without the need for any other solvent or promoter, affording yields of 92%-99% within 2-7 min at room temperature. When L-proline is used as an additional promoter to obtain coumarins from o-hydroxybenzaldehydes, the reaction also proceeds in high yields. Work-up is very simple and the ionic liquid can be reused several times. Some of the coumarins obtained are described for the first time.

相关化合物

  • 丙二腈
  • 5-溴-2-羟基-3-甲氧...
  • 硫酸甲酯钠
  • 甲烷磺酰基乙酸乙酯

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