Journal of Biomedical Materials Research 2000-08-01

Covalent surface chemical modification of electrodes for cardiac pacing applications.

M H Schoenfisch, M Ovadia, J E Pemberton

文献索引：J. Biomed. Mater. Res. 51(2) , 209-15, (2000)

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摘要

We report the covalent surface modification of active-fixation pacemaker electrodes with butanethiol or dodecanethiol self-assembled monolayers (SAMs) using a platinum or gold metal-thiolate bond (i.e., changing the chemical identity of the exposed metal electrode from metal to organic) in such fashion that (a) the surface is organic in functionality with lipophilic physicochemical characteristics, (b) a possible degradation product is gold (I)-alkanethiolate with putative anti-inflammatory actions, and (c) current density/electric field strength is increased. Superior acute and chronic pacing performance with dodecanethiol-modified, gold-coated, platinum-iridium alloy pacemaker electrodes was observed with inferential evidence of reduced inflammation and scar. This approach may have applicability in other areas of bioelectrodes with practical applications in clinical cardiology, surgery, neuroscience, and subcutaneous sensors.Copyright 2000 John Wiley & Sons, Inc.

相关化合物

  • 正丁硫醇
  • 1-丁烷硫醇钠

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