Enzyme and Microbial Technology 2016-03-01

First Novozym 435 lipase-catalyzed Morita-Baylis-Hillman reaction in the presence of amides.

Xuemei Tian, Suoqin Zhang, Liangyu Zheng

文献索引：Enzyme Microb. Technol. 84 , 32-40, (2016)

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摘要

The first Novozym 435 lipase-catalyzed Morita-Baylis-Hillman (MBH) reaction with amides as co-catalyst was realized. Results showed that neither Novozym 435 nor amide can independently catalyze the reaction. This co-catalytic system that used a catalytic amount of Novozym 435 with a corresponding amount of amide was established and optimized. The MBH reaction strongly depended on the structure of aldehyde substrate, amide co-catalyst, and reaction additives. The optimized reaction yield (43.4%) was achieved in the Novozym 435-catalyzed MBH reaction of 2, 4-dinitrobenzaldehyde and cyclohexenone with isonicotinamide as co-catalyst and β-cyclodextrin as additive only in 2 days. Although enantioselectivity of Novozym 435 was not found, the results were still significant because an MBH reaction using lipase as biocatalyst was realized for the first time. Copyright © 2015 Elsevier Inc. All rights reserved.

相关化合物

  • 对氯苯甲醛
  • 吡啶酰胺
  • 对氟苯甲醛

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