Journal of Organic Chemistry 2011-04-01

Sequential one-pot ruthenium-catalyzed azide-alkyne cycloaddition from primary alkyl halides and sodium azide.

Johan R Johansson, Per Lincoln, Bengt Nordén, Nina Kann

文献索引：J. Org. Chem. 76(7) , 2355-9, (2011)

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摘要

An experimentally simple sequential one-pot RuAAC reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields starting from an alkyl halide, sodium azide, and an alkyne, is reported. The organic azide is formed in situ by treating the primary alkyl halide with sodium azide in DMA under microwave heating. Subsequent addition of [RuClCp*(PPh(3))(2)] and the alkyne yielded the desired cycloaddition product after further microwave irradiation.

相关化合物

  • 3-甲氧基苄溴
  • 4-苯氧基溴丁烷
  • 3-乙炔基吡啶
  • 4-氟苯乙炔

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