Phytotherapy Research 2015-06-01

Inhibition of Cancer Cell Proliferation and Antiradical Effects of Decoction, Hydroalcoholic Extract, and Principal Constituents of Hemidesmus indicus R. Br.

Giancarlo Statti, Mariangela Marrelli, Filomena Conforti, Antonella Spagnoletti, Massimo Tacchini, Carmela Fimognari, Eleonora Brognara, Roberto Gambari, Gianni Sacchetti, Alessandra Guerrini

文献索引:Phytother Res. 29 , 857-63, (2015)

全文:HTML全文

摘要

Indian Sarsaparilla (Hemidesmus indicus R. Br.) is widely used in Indian traditional medicine. In the present work, we explored the effects of decoction, traditional Ayurvedic preparation, and hydroalcoholic extract, a phytocomplex more traditionally studied and commercialized as food supplement in western medicine, from the roots as possible source of chemicals with new functional potential linked to their nutritional uses. The antiproliferative and antioxidant properties were assayed. To test antiproliferative affects, different cancer cell lines, growing both as monolayers (CaCo2, MCF-7, A549, K562, MDA-MB-231, Jurkat, HepG2, and LoVo) and in suspension (K562 and Jurkat) were used. The decoction showed strong activity on HepG2 cells, while the hydroalcoholic extracts were active on HepG2, LoVo, MCF-7, K562, and Jurkat cell lines. Weak inhibition of cancer cell proliferation was observed for the principal constituents of the preparations: 2-hydroxy-4-methoxybenzaldehyde, 2-hydroxy-4-methoxybenzoic acid, and 3-hydroxy-4-methoxybenzaldehyde that were tested alone. The antiradical activity was tested with 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt tests and inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages. Interesting result has also been obtained for hydroalcoholic extract regarding genoprotective potential (58.79% of inhibition at 37.5 µg/mL).Copyright © 2015 John Wiley & Sons, Ltd.


相关化合物

  • 2,2-联苯基-1-苦基...
  • 没食子酸; 3,4,5-三...
  • 金丝桃苷
  • 1,1-二苯基-2-苦味...
  • L-谷氨酰胺
  • 直接蓝 14
  • 2-羟基-4-甲氧基苯...
  • 4-甲氧基水杨酸
  • 氯化矢车菊素
  • 异香兰素; 3-羟基-...

相关文献:

Pectin Micro- and Nano-capsules of Retinyl Palmitate as Cosmeceutical Carriers for Stabilized Skin Transport.

2015-01-01

[Korean J. Physiol. Pharmacol. 19(1) , 59-64, (2015)]

Coffee silverskin: a possible valuable cosmetic ingredient.

2015-03-01

[Pharm. Biol. 53(3) , 386-94, (2015)]

Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity.

2015-03-14

[Br. J. Nutr. 113(5) , 770-82, (2015)]

Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS.

2015-01-01

[Molecules 20 , 11490-507, (2015)]

Assessing the bioavailability of polyphenols and antioxidant properties of extra virgin argan oil by simulated digestion and Caco-2 cell assays. Comparative study with extra virgin olive oil.

2015-12-01

[Food Chem. 188 , 496-503, (2015)]

更多文献...