Journal of the American Chemical Society
2005-04-06
Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents.
Christian Fischer, Gregory C Fu
文献索引：J. Am. Chem. Soc. 127 , 4594, (2005)
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摘要
A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.