Organic Letters 2002-11-14

Highly efficient synthesis of chiral beta-amino acid derivatives via asymmetric hydrogenation.

Wenjun Tang, Xumu Zhang

文献索引：Org. Lett. 4 , 4159, (2002)

全文：HTML全文

摘要

The Rh-TangPhos complex is an efficient hydrogenation catalyst for making chiral beta-amino acid derivatives. With the Rh-TangPhos system, high enantioselectivities (up to 99.6%) and turnover numbers have been obtained in the hydrogenation of E/Z isomeric mixtures of both beta-alkyl and beta-aryl beta-(acylamino)acrylates. [reaction: see text]

相关化合物

  • 1,1'-二叔丁基二磷...

相关文献：

Asymmetric hydrogenation of itaconic acid and enol acetate derivatives with the Rh-TangPhos catalyst.

2003-01-23

[Org. Lett. 5 , 205, (2003)]

A chiral 1,2-bisphospholane ligand with a novel structural motif: applications in highly enantioselective Rh-catalyzed hydrogenations.

2002-05-03

[Angew. Chem. Int. Ed. Engl. 41 , 1612, (2002)]

Axtell, A. T. et al.

[Organometallics 25 , 5003, (2006)]

更多文献...