Food and Chemical Toxicology 2014-06-01

Application of the equivalency factor concept to the phototoxicity and –genotoxicity of furocoumarin mixtures

Nicole Raquet, Dieter Schrenk

文献索引：Food Chem. Toxicol. 68 , 257-66, (2014)

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摘要

• The photo-cytotoxic, -mutagenic, and -clastogenic properties in V79 cells of thirteen furocoumarins (FCs), were analyzed. • Nine FC mixtures including one mixture ‘representing’ FCs in Angelica archangelica extract were tested. • The concept of relative potency factors for photo-cytotoxicity, -mutagenicity, and -clastogenicity was applicable to all congeners. • The concept was applied successfully to binary mixtures of 5- and 8-methoxypsoralen and to complex FC mixtures.

相关化合物

  • 水
  • 香柑醇； 5-羟基-6,...
  • 花椒毒素； 8-甲氧...
  • 异茴芹灵
  • 异补骨脂素
  • 补骨脂素
  • 佛手柑内酯

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