Chemical & Pharmaceutical Bulletin 2000-10-01

Rate enhancement with high ratio of the monoalkylated product to the dialkylated product in the alkylation of the lithium enolate of 1-tetralone with reactive alkyl halides.

M Goto, K Akimoto, K Aoki, M Shindo, K Koga

文献索引：Chem. Pharm. Bull. 48(10) , 1529-31, (2000)

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摘要

The reactions of the lithium enolate of 1-tetralone with reactive alkyl halides were examined in the absence and in the presence of 3 eq of various ligands for the lithium. It is shown that the rates of the reactions are enhanced greatly in the presence a tetradentate amine (1,1,4,7,10,10-hexamethyltriethylenetetramine), and the ratio of the monoalkylated product to the dialkylated product is increased under shorter reaction times.

相关化合物

  • β-四氢萘酮

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