Planta Medica 2002-05-01

Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.

Hyuncheol Oh, Ho-Sub Lee, Taewan Kim, Kyu-Yun Chai, Hun-Taeg Chung, Tae-Oh Kwon, Jung-Yang Jun, Ok-Sam Jeong, Youn-Chul Kim, Young-Gab Yun

文献索引：Planta Med. 68(5) , 463-4, (2002)

全文：HTML全文

摘要

Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (+/-)-byakangelicol (3), (+)-oxypeucedanin (4), (+)-byakangelicin (5), and (+)-aviprin (6). Among these, compounds 1 and 5 exhibited strong hepatoprotective activities, displaying EC(50) values of 36.6 +/- 0.98 and 47.9 +/- 4.6 microM, respectively. Compounds 3 and 4 showed moderate activities with EC(50) values of 112.7 +/- 5.35 and 286.7 +/- 6.36 microM, respectively. Silybin as a positive control showed the EC(50) value with 69.0 +/- 3.4 microM. Comparison of hepatoprotective activities for six furocoumarins 1 - 6 suggested that oxy-substitution at the C-9 position increased the hepatoprotective activity.

相关化合物

  • 白当归素

相关文献：

Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.

2001-04-05

[J. Chromatogr. B. Biomed. Sci. Appl. 753(2) , 309-14, (2001)]

[Studies on quality standards of radix Angelicae dahuricae].

2004-07-01

[Zhongguo Zhong Yao Za Zhi 29(7) , 654-7, (2004)]

High-performance liquid chromatographic method for the determination and pharmacokinetic study of oxypeucedanin hydrate and byak-angelicin after oral administration of Angelica dahurica extracts in mongrel dog plasma.

2007-05-09

[J. Pharm. Biomed. Anal. 44(1) , 166-72, (2007)]

Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.

2011-01-01

[Br. J. Pharmacol. 162(2) , 441-51, (2011)]

Crystal structure of byakangelicin (C17H18O7).

2002-06-01

[Arch. Pharm. Res. 25(3) , 275-9, (2002)]

更多文献...