Journal of Biomolecular Structure and Dynamics 1995-04-01

Conformational energies of substrates and inhibitors for carboxypeptidase A: stereoelectronic effect.

J K Park, S J Cho, S Lee, K S Kim, D H Kim

文献索引：J. Biomol. Struct. Dyn. 12(5) , 1033-40, (1995)

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摘要

Because of the complexity involved in binding of a ligand to an enzyme the conformational preference of the bound ligand has not been well understood yet. We have examined the conformational energies of ligands for carboxypeptidase A using ab initio calculations. Considering the large stereoelectronic effect of 4-5 kcal/mol, the energetic preference of the unbound ligand conformers which arises from the stereoelectronic effect appears to play a significant role in determining the bound ligand conformations.

相关化合物

  • n-乙酰-d-苯丙氨酸
  • 甘氨酰-L-酪氨酸水...
  • N-乙酰-L-苯丙氨酸

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