Neuroscience Letters 2011-03-17

Effects of optimized-SopungSunkiwon on memory impairment and enhancement.

Jin Gyu Choi, Woong Mo Yang, Tong Ho Kang, Myung Sook Oh

文献索引：Neurosci. Lett. 491(2) , 93-8, (2011)

全文：HTML全文

摘要

Optimized-SopungSunkiwon (OSS) is a multi-herbal formula that contains six medicinal herbs from SopungSunkiwon, a traditional medicine used for neurodegenerative disorders. In this study, we investigated the anti-amnesic effects of OSS in a dementia model. Acetylcholinesterase (AChE) inhibition assay was performed to investigate the cholinergic antagonistic effect of OSS. In addition, a step-through passive-avoidance test was performed with scopolamine-induced memory impairment in mice, and immunohistochemistry was analyzed to investigate synaptic formation with synaptic proteins. OSS inhibited AChE activity, resulting in significant improvement of memory functions. In the passive-avoidance test, the latency time of OSS-treated mice was significantly longer than that of either the control or scopolamine-treated group. In the immunohistochemical analysis, synaptic proteins such as synaptophysin and PSD-95 were significantly increased in OSS-treated mice. These results demonstrate that OSS may affect impairment and enhancement of memory and increase synaptophysin and PSD-95 facilitating acetylcholine release and synaptic growth.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

相关化合物

  • 番泻苷B
  • 番泻苷A

相关文献：

The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice.

2012-01-01

[Biol. Pharm. Bull. 35(12) , 2204-8, (2012)]

The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice.

2011-01-01

[Biol. Pharm. Bull. 34(9) , 1438-42, (2011)]

Simple and rapid analysis of sennoside A and sennoside B contained in crude drugs and crude drug products by solid-phase extraction and high-performance liquid chromatography.

2010-04-01

[J. Nat. Med. 64(2) , 126-32, (2010)]

Prospective randomized comparison of oral sodium phosphate and sennoside A+B calcium lavage for colonoscopy preparation.

2011-04-01

[Surg. Laparosc. Endosc. Percutan. Tech. 21(2) , 90-3, (2011)]

Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery

2012-04-01

[Asian J. Surg. 35(2) , 81-7, (2012)]

更多文献...