A rapid method for the synthesis of methylmalonyl-coenzyme A and other CoA-esters.
R Padmakumar, S Gantla, R Banerjee
文献索引:Anal. Biochem. 214(1) , 318-20, (1993)
全文:HTML全文
摘要
A rapid and high-yield synthesis of methylmalonyl coenzyme A is reported. The two-step procedure involves preparation of the thiophenyl ester of methylmalonic acid using dicyclohexylcarbodiimide as a condensing agent, followed by transesterification with coenzyme A, to yield methylmalonyl coenzyme A in 80% overall yield. Inclusion of an additional step, methylation of malonic acid with iodomethane, affords the opportunity for introducing a stable or radioactive isotope into the product. This method should be applicable for the syntheses of other coenzyme A esters that are of biochemical interest such as succinyl coenzyme A.
相关化合物
相关文献:
2015-11-01
[J. Mol. Cell. Cardiol. 88 , 73-81, (2015)]
2006-04-03
[Angew. Chem. Int. Ed. Engl. 45(15) , 2466-9, (2006)]
2004-09-07
[Org. Biomol. Chem. 2(17) , 2411-4, (2004)]
1998-03-17
[Biochemistry 37(11) , 3876-85, (1998)]
2000-03-01
[Chem. Pharm. Bull. 48(3) , 405-9, (2000)]