Bioorganic & Medicinal Chemistry Letters 2007-09-01

Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.

Il Hong Son, Ill-Min Chung, Sung Ik Lee, Hyun Duk Yang, Hyung-In Moon

文献索引：Bioorg. Med. Chem. Lett. 17(17) , 4753-5, (2007)

全文：HTML全文

摘要

The major constituents from the fruits of Maclura pomifera are the prenylated isoflavones, osajin (1) and pomiferin (2). Their structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 2 showed potential inhibitory activity in histone deacetylase (HDAC) enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the HCT-15 colon tumor cell line. Further structure-activity relationships of position 3 on ring B from aromatic ring will be reported in due course.

相关化合物

  • 奥沙京

相关文献：

Interactions of genistein and related isoflavones with lipid micelles.

2006-08-15

[Langmuir 22(17) , 7175-84, (2006)]

Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide.

2008-09-10

[J. Pharm. Biomed. Anal. 48(1) , 127-33, (2008)]

Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin.

2011-01-01

[PLoS ONE 6(4) , e18308, (2011)]

Examining the genomic influence of skin antioxidants in vitro.

2010-01-01

[Mediators Inflamm. 2010 , 230450, (2010)]

Protective effects of osajin in ischemia-reperfusion of laboratory rat kidney.

2006-06-01

[Pharmazie 61(6) , 552-5, (2006)]

更多文献...