Indian journal of physiology and pharmacology 1985-01-01

Levels of acetyl hydrazines and rate of acetylation of isoniazid in adult tuberculosis patients.

E B Bhalerao, S V Bhide

文献索引：Indian J. Physiol. Pharmacol. 29(2) , 83-8, (1985)

全文：HTML全文

摘要

Patients suffering from pulmonary tuberculosis were investigated for the levels of isoniazid (INH) and its metabolites viz. acetyl-INH, mono and diacetyl hydrazines and ammonia. It was observed that 50% of the patients are slow inactivators of INH and almost all show an increase in circulating levels of NH3 at 6 hrs. Mono and diacetyl hydrazine levels in blood and urine were detectable in all the patients up+o 24 hrs though the maximum levels were observed at different intervals after the intake of INH.

相关化合物

  • N,N'-二乙酰基肼

相关文献：

A charged aerosol detector/chemiluminescent nitrogen detector/liquid chromatography/mass spectrometry system for regular and fragment compound analysis in drug discovery.

2015-09-11

[J. Chromatogr. A. 1411 , 63-8, (2015)]

Urinary metabolic profile of isoniazid in patients who develop isoniazid-related liver damage.

1984-12-01

[Hum. Toxicol. 3(6) , 485-95, (1984)]

Effect of isoniazid on folic acid status in Swiss mice and rats.

1985-01-01

[Indian J. Physiol. Pharmacol. 29(3) , 133-8, (1985)]

Double N-H bond activation of N,N'-bis-substituted hydrazines with stable N-heterocyclic silylene.

2012-02-07

[Dalton Trans. 41(5) , 1529-33, (2012)]

Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans.

1985-12-01

[J. Pharmacol. Exp. Ther. 235(3) , 566-70, (1985)]

更多文献...