Journal of Natural Products 2007-08-01

Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.

Peter L Katavic, Kenneth Lamb, Hernan Navarro, Thomas E Prisinzano

文献索引：J. Nat. Prod. 70 , 1278-82, (2007)

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摘要

Flavonoids have been recognized as the active ingredients of many medicinal plant extracts due to interactions with proteins via phenolic groups and low toxicity. Here, we report the investigation of the flavonoid core as a potential new scaffold for the development of opioid receptor ligands. Biological results suggest that stereochemistry of the C2 and C3 positions is important for antagonist activity and selectivity. Our results also suggest that the actions of Hypericum perforatum may be mediated in part by opioid receptors.

相关化合物

  • 表儿茶素(EC)
  • 芹菜素; 芹黄素; 5,...
  • 表儿茶素没食子酸酯
  • 表没食子儿茶素
  • 异槲皮苷
  • 穗花杉双黄酮； 阿...
  • 大豆苷元
  • (-)-没食子酸儿茶素...
  • (-)-儿茶素

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