Journal of the American Chemical Society 2010-11-10

Asymmetric bromolactonization using amino-thiocarbamate catalyst.

Ling Zhou, Chong Kiat Tan, Xiaojian Jiang, Feng Chen, Ying-Yeung Yeung

文献索引：J. Am. Chem. Soc. 44th ed., 132 , 15474-15476, (2010)

全文：HTML全文

摘要

A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of γ-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists.

相关化合物

  • 甲基硼酸

相关文献：

Effect of co-ligands on chemical and biological properties of (99m)Tc(III) complexes [(99m)Tc(L)(CDO)(CDOH)2BMe] (L=Cl, F, SCN and N3; CDOH2=cyclohexanedione dioxime).

2014-01-01

[Nucl. Med. Biol. 41(10) , 813-24, (2014)]

Enantioselective bromoaminocyclization using amino-thiocarbamate catalysts.

2011-06-22

[J. Am. Chem. Soc. 133 , 9164-9167, (2011)]

Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discovery.

2011-05-11

[J. Am. Chem. Soc. 18th ed., 133 , 7222-7228, (2011)]

Suzuki-Miyaura cross-couplings of secondary allylic boronic esters.

2012-01-30

[Chem. Commun. (Camb.) 9th ed., 48 , 1230-1232, (2012)]

Enol tosylates as viable partners in Pd-catalyzed cross-coupling reactions.

2005-11-25

[J. Org. Chem. 70 , 10124, (2005)]

更多文献...