Macromolecular Bioscience 2012-05-01

Photo-crosslinked biodegradable hydrogels prepared from fumaric acid monoethyl ester-functionalized oligomers for protein delivery.

Janine Jansen, George Mihov, Jan Feijen, Dirk W Grijpma

文献索引：Macromol. Biosci. 12(5) , 692-702, (2012)

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摘要

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trimethylene carbonate or a mixture of these monomers. Two model proteins, lysozyme and albumin, are incorporated in the hydrogels and their release is studied. The composition of the hydrophobic segments could be used to tune degradation behavior and release rates. Careful optimization of photo-polymerization conditions is needed to limit conjugation of proteins to the hydrogels and protein denaturation.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

相关化合物

  • 富马酸单乙基酯钙盐
  • DL-丙交酯
  • N-乙烯基吡咯烷酮
  • 富马酸单乙酯

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