Improved biological effects of uniconazole using porous hollow silica nanoparticles as carriers.

Wei-Ming Tan, Ning Hou, Sen Pang, Xiao-Feng Zhu, Zhao-Hu Li, Li-Xiong Wen, Liu-Sheng Duan

文献索引：Pest Manag. Sci. 68(3) , 437-43, (2012)

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摘要

The aim of this work is to prepare a controlled-release formulation of uniconazole using porous hollow silica nanoparticles (PHSNs) as carrier, and to investigate the biological effects on rice growth.PHSNs with a shell thickness of ~15 nm and a particle size of 80-100 nm were synthesised through a sol-gel route using nanosized calcium carbonate particles as templates. Simple immersing (SI) and supercritical fluid drug loading (SFDL) technologies were employed to load uniconazole into PHSNs with loading efficiencies of ~22 and ~26% respectively. The prepared uniconazole-loaded PHSNs (UCZ-PHSNs) by SI and SFDL both demonstrated sustained release properties, and the latter showed better controlled release ability with a slower release rate. Compared with free uniconazole, UCZ-PHSNs exhibited a weaker growth retardation effect in the early stage but more significant retardation ability in later stages for agar-cultured rice seedlings. For the rice that grew in clay, UCZ-PHSNs demonstrated a weaker plant height retardation effect than free uniconazole at the early jointing stage by foliar spraying, but exhibited a stronger retardation capacity than free uniconazole by being applied into soil before seedling transplantation.The results indicated that the prepared UCZ-PHSNs possessed good controlled-release properties and had improved retardation effects on rice growth. It is recommended that UCZ-PHSNs be applied into soil before seedling transplantation rather than administered by foliar spraying at the early jointing stage.Copyright © 2011 Society of Chemical Industry.