Online ESI-MS analysis of reactions under high pressure.
Roberto A Paz-Schmidt, Werner Bonrath, Dietmar A Plattner
文献索引：Anal. Chem. 81(9) , 3665-8, (2009)
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摘要
A new approach for real-time mass spectrometric analysis and identification of intermediates in confined, pressurized vessels is presented. The high-pressure reaction media is depressurized, mixed with a solvent, and fed directly to the atmospheric pressure electrospray ionization source of a tandem mass spectrometer. The method was applied to track product evolution for the dehydration of hydroxenin monoacetate, a commercially, important vitamin A precursor, and for the hydrogenation of 5-norbornene-2-carbonitrile with Pd/CaCO(3) as catalyst. Faster access but comparable results as by conventional off-line methods were obtained in every case.