[Serial determination of crimidine by HPLC/SE/SM in a patient ingesting a "mouse trap"].

T Besnard, N Sadeg, N Ricart, J Richecoeur, P Nisse, E Vinner, N Houdret, L Humbert, M Ihermitte

文献索引：Acta Clin. Belg. Suppl. (1) , 8-11, (2002)

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摘要

Crimidine (2 chloro, 4 methyl, 6 dimethyl amidopyrine) is a synthetic rodenticide which causes acute poisonings after oral ingestion in human. Major toxic effects are consciousness disorders, hypertonic coma and convulsions. Toxic level in human is about 5 mg/Kg. An intoxication case is reported. Five serums collected at different times were analyzed with HPLC/ES/MS. Crimidine was extracted with ethylacetate with recovery over 80%. Linearity was up to 800 micrograms/L. LOQ and LOD were 0.5 and 0.3 microgram/L respectively. The coefficients of variation were less than 10% for repeatability and reproductibility. Serum levels varied from 368 micrograms/L for H0 to 64 micrograms/L for H10 and elimination of crimidine was linear in time.