Journal of Pharmaceutical Sciences 1981-11-01

Solubility behavior of phenolic compounds in hexane-ethyl acetate, hexane-ethyl myristate, and hexane-ethyl pivalate cosolvent systems.

E Akaho, K Iga, J Kraal, A Hussain

文献索引：J. Pharm. Sci. 70(11) , 1225-8, (1981)

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摘要

Interactions of phenolic compounds 4-hexylresorcinol and 3,4-dimethylphenol with esters were studied using hexane-ester cosolvent systems by both phase solubility and partitioning methods. The data obtained by the phase solubility method were variable and could not be analyzed by any mathematical model. The data obtained by the partitioning method, however, strongly suggest that 4-hexylresorcinol forms 1:1 and 1:2 complexes with the esters in hexane, while 3,4-dimethylphenol forms only 1:1 complexes with the same esters.

相关化合物

  • 十四酸乙酯
  • 特戊酸乙酯

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