Bioorganic & Medicinal Chemistry Letters 2010-07-15

Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.

Markus A Altmeyer, Aline Marschner, Rolf Schiffmann, Christian D Klein

文献索引：Bioorg. Med. Chem. Lett. 20 , 4038-44, (2010)

全文：HTML全文

摘要

Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic study on the subtype- and species-selectivity of MetAP inhibitors that require the binding of an auxiliary metal ion. This includes, in particular, compounds based on the benzimidazole pharmacophore, but also hydroxyquinoline and picolinic acid derivatives. Our data indicates that a significant degree of selectivity can be attained with metal-dependent MetAP inhibitors.2010 Elsevier Ltd. All rights reserved.

相关化合物

  • 8-羟基喹啉
  • 甲苯咪唑
  • 阿苯达唑
  • 噻菌灵
  • 多菌灵
  • 麦穗灵

相关文献：

Selective growth-inhibitory effect of 8-hydroxyquinoline towards Clostridium difficile and Bifidobacterium longum subsp. longum in co-culture analysed by flow cytometry.

2014-12-01

[J. Med. Microbiol. 63(Pt 12) , 1663-9, (2014)]

Synthesis of a monofunctional platinum compound and its activity alone and in combination with phytochemicals in ovarian tumor models.

2014-12-01

[Anticancer Res. 34(12) , 7077-90, (2014)]

An analytical quality by design (aQbD) approach for a L-asparaginase activity method.

2016-01-05

[J. Pharm. Biomed. Anal. 117 , 232-9, (2015)]

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

2011-01-27

[J. Med. Chem. 54 , 591-602, (2011)]

Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis.

2015-03-06

[Eur. J. Med. Chem. 92 , 302-13, (2015)]

更多文献...