Chemistry An Asian Journal 2006-07-17

Nucleophilic activation of alkenyl and aryl boronates by a chiral Cu(I)F complex: catalytic enantioselective alkenylation and arylation of aldehydes.

Daisuke Tomita, Motomu Kanai, Masakatsu Shibasaki

文献索引：Chem. Asian J. 1(1-2) , 161-6, (2006)

全文：HTML全文

摘要

A new method for the catalytic enantioselective alkenylation and arylation of aldehydes involves the activation of alkenyl and aryl boronates by a catalytic amount of the Cu(I)F-DTBM-segphos complex through transmetalation, generating novel alkenyl and aryl copper species. These reagents act as the actual nucleophile. A range of aldehydes can be converted into optically active secondary allyl alcohols or diaryl methanols with excellent enantioselectivity. The appropriate choice of additives, depending on the substrate, is critical to ensure high yields of products. These additives possibly modulate the catalyst turnover step from copper alkoxide intermediates generated by the addition of organocopper reagents to aldehydes.

相关化合物

  • 氟化铜

相关文献：

Catalytic enantioselective aldol reaction to ketones.

2006-06-07

[J. Am. Chem. Soc. 128 , 7164, (2006)]

The effect of various fluoride compounds on the development of experimental root surface caries in hamsters.

1995-12-01

[Bull. Tokyo Med. Dent. Univ. 42(3) , 105-16, (1995)]

[Effect of fluoride of copper and iron on polymerization of MMA/TBBO resin and adhesion to dentin].

1989-05-01

[Shika Zairyo. Kikai 8(3) , 425-30, (1989)]

[Study on adhesion mechanism of MMA-TBBO resin to dentin. A model experiment using decalcified dentin].

1990-03-01

[Shika Zairyo. Kikai 9(2) , 320-5, (1990)]

Effect of copper fluoride and copper sulfate on dental plaque, Streptococcus mutans and caries in hamsters.

1988-10-01

[Scand. J. Dent. Res. 96(5) , 390-2, (1988)]

更多文献...