Acta poloniae pharmaceutica 2013-01-01

Netilmicin-induced modulation of melanogenesis in HEMa-LP melanocytes.

Dorota Wrześniok, Artur Beberok, Michał Otreba, Ewa Buszman

文献索引：Acta Pol. Pharm. 70(5) , 803-8, (2013)

全文：HTML全文

摘要

It is known that aminoglycoside antibiotics bind well to melanin biopolymer, but the relation between their affinity to melanin and ototoxicity is not well established. The aim of this work was to examine the impact of netilmicin on melanogenesis in cultured normal human melanocytes (HEMa-LP). The WST-1 assay was used to detect netilmicin cytotoxic effect. Netilmicin induced concentration-dependent loss in melanocytes viability. The value of EC50 was found to be - 75.0 mM. The analyzed antibiotic inhibited melanin biosynthesis in a concentration-dependent manner. Increasing the drug concentration resulted also in a decrease of cellular tyrosinase activity. Netilmicin-induced modulation of melanogenesis in melanocytes in vitro may explain a potential role of melanin and melanocytes in the mechanisms of aminoglycosides ototoxic effects in vivo.

相关化合物

  • 左旋多巴
  • 奈替米星硫酸盐
  • 乙二胺四乙酸
  • 酪氨酸酶

相关文献：

Insights from reconstitution reactions of COPII vesicle formation using pure components and low mechanical perturbation.

2014-07-01

[Biol. Chem. 395(7-8) , 801-12, (2014)]

Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats.

2015-02-01

[Neurobiol. Dis. 74 , 295-304, (2015)]

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.

2014-09-01

[J. Pharmacol. Exp. Ther. 350(3) , 589-604, (2014)]

Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways.

2015-01-01

[Int. J. Mol. Sci. 16 , 24219-42, (2015)]

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

2010-01-01

[Chem. Res. Toxicol. 23 , 171-83, (2010)]

更多文献...