Fatal intoxication with milnacipran
Laurent Fanton, Fabien Bévalot, Habdelhamid Grait, Catherine Le Meur, Yvan Gaillard, Daniel Malicier, Laurent Fanton, Fabien Bévalot, Habdelhamid Grait, Catherine Le Meur, Yvan Gaillard, Daniel Malicier
文献索引:J. Forensic Leg. Med. 15(6) , 388-90, (2008)
全文:HTML全文
摘要
The antidepressant milnacipran is a double serotonin/noradrenalin reuptake inhibitor. The low reported incidence of intoxication indicates excellent tolerance in comparison with tricyclic and second generation antidepressants. We report a fatal intoxication associating milnacipran, at blood levels (femoral = 21.5 mg/l, cardiac = 20 mg/l) 40-fold higher than the usual treatment concentration, and six other molecules (fluoxetine, norfluoxetine, sertraline, cyamemazine, nordazepam and oxazepam) at therapeutic levels. To the best of our knowledge, this is the first reported fatal intoxication involving milnacipran.
相关化合物
相关文献:
2015-01-15
[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 975 , 24-33, (2014)]
2005-05-05
[J. Med. Chem. 48 , 3269-79, (2005)]
2014-10-01
[Forensic Sci. Int. 243 , 99-106, (2014)]
2014-10-01
[Forensic Sci. Int. 243 , 149-55, (2014)]
2014-11-01
[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014)]