Catalytic enantioselective synthesis of quaternary all-carbon stereogenic centers. Preparation of alpha,alpha'-disubstituted beta,gamma-unsaturated esters through Cu-catalyzed asymmetric allylic alkylations.
Kerry E Murphy, Amir H Hoveyda
文献索引:Org. Lett. 7 , 1255, (2005)
全文:HTML全文
摘要
[reaction: see text] Peptide-based chiral ligands, readily prepared from commercially available materials, are used to promote Cu-catalyzed asymmetric allylic alkylations of alpha,beta-unsaturated esters bearing a gamma-phosphate with various alkylzinc reagents. These transformations lead to the formation of alpha,alpha'-dialkyl-beta,gamma-unsaturated esters in high yields as well as high regio- (re) and enantioselectivities (ee).
相关化合物
相关文献:
2002-05-17
[J. Org. Chem. 67 , 3450, (2002)]
1996-07-15
[Biochem. J. 317 ( Pt 2) , 395-402, (1996)]
Moore, J. A.; Partain, E. M.
[J. Org. Chem. 48 , 1105, (1983)]
Bethell, D.; Jenkins, I. L.; Quan, P. M.
[J. Chem. Soc., Perkin Trans. II , 1789, (1985)]
Paryzek, Z.; Martynow, J.
[J. Chem. Soc. Perkin Trans. I , 599, (1990)]