Experimental & molecular medicine 2015-01-01

Epstein-Barr virus latent genes.

Myung-Soo Kang, Elliott Kieff

文献索引：Exp. Mol. Med. 47 , e131, (2015)

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摘要

Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent with the notion that EBV latent genes are important for malignant cell growth. While the EBV-encoded nuclear antigen-1 (EBNA-1) and latent membrane protein-2A (LMP-2A) are critical, the EBNA-leader proteins, EBNA-2, EBNA-3A, EBNA-3C and LMP-1, are individually essential for in vitro transformation of primary B cells to lymphoblastoid cell lines. EBV-encoded RNAs and EBNA-3Bs are dispensable. In this review, the roles of EBV latent genes are summarized.

相关化合物

  • 胆固醇
  • 甘氨酰-L-丙氨酸
  • DL-酪氨酸
  • 荧光素
  • DL-2-氨基丙酸

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