Enzymatic amine acyl exchange in peptides on gold surfaces.
Roberto Castangia, Martina Austeri, Sabine L Flitsch
文献索引:Angew. Chem. Int. Ed. Engl. 51(52) , 13016-8, (2012)
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摘要
Reversible as well as stereo- and chemoselective: various proteases such as thermolysin and chymotrypsin catalyze amine acyl exchange in peptides. This acyl exchange can be used to modify amino-functionalized surfaces under physiological reaction conditions and provides an alternative mechanism for posttranslational transpeptidation reactions such as peptide-splicing reactions in the proteasome.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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