Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands.

Luca Boselli, Isabelle Ader, Maëlle Carraz, Catherine Hemmert, Olivier Cuvillier, Heinz Gornitzka

文献索引：Eur. J. Med. Chem. 85 , 87-94, (2014)

全文：HTML全文

摘要

New gold(I) complexes containing two 1-[2-(diethylamino)ethyl]imidazolydene ligands have been synthesized and characterized. The X-ray structures of two key compounds are presented. All complexes have been tested for their antiproliferative activities in prostate cancer cell line PC-3. Lipophilicity (Log P) has been determined for these complexes. The most active complex has been tested for the cytotoxic activities in five human cancer cell lines and primary endothelial cells. The most active complex demonstrated a potent selectivity for cancer cells. Copyright © 2014 Elsevier Masson SAS. All rights reserved.