Pd-mBDPP-catalyzed regioselective internal arylation of electron-rich olefins by aryl halides.
Shifang Liu, Neil Berry, Nick Thomson, Alan Pettman, Zeynab Hyder, Jun Mo, Jianliang Xiao
文献索引:J. Org. Chem. 71(19) , 7467-70, (2006)
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摘要
meso-2,4-Bis(diphenylphosphino)pentane (mBDPP) has proved to be an effective regiocontrolling ligand for palladium-catalyzed internal arylation by aryl bromides of electron-rich olefins in a common solvent DMSO with no need for any halide scavengers. The arylation of the benchmark electron-rich olefin butyl vinyl ether took place smoothly to afford exclusively alpha-arylated product with high isolated yields. The better performance of mBDPP, compared with that of the commonly used DPPP [1,3-bis(diphenylphosphino)propane], highlights the important but subtle effect of ligand on the regioselectivity of the Heck arylation reactions.
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1995-05-01
[J. Toxicol. Sci. 20(2) , 161-4, (1995)]