[The impact of N, N-dimethylacetamide on the health of workers].

Yan-yan Lu, Hao Wu, Hong-fang Tang, Zheng Ruan, Dan-hua Liu, Cheng-min Xu, Ya-ling Qian

文献索引：Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29(11) , 834-6, (2011)

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摘要

To explore the hepatic toxicity and the exposure biomarkers of N, N-Dimethylacetamide.One hundred forty five objects were chosen by stratified random sampling method. The investigation was performed using questionnaire and physical examination. The air concentrations of DMAC in the workshops were monitored. The urine samples were collected and analyzed after work everyday or at the weekend. The correlation between the air concentrations of DMAC in the workshops and the concentrations of urinary NMAC wee analyzed by regression.The air concentration of DMAC in the spinning workshop was higher than others. The morbidity of abnormal hepatic function was 12.4%, 61.1% of workers with abnormal hepatic function appeared in one year after exposure to DMAC in the workshops ( r=0.44, P<0.01).The abnormal heptic function was found in workers exposed to DMAC for short period. The concentration of urinary NMAC can serve as the exposure biomarker of DMAC.