Chemioterapia : international journal of the Mediterranean Society of Chemotherapy 1986-08-01

Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10).

S D'Ancona, G Magnolfi, G Guidetti, G Toffoli, A Lazzarini, M Carrara, M Magon, S Luciani, T Berti

文献索引：Chemioterapia 5(4) , 219-27, (1986)

全文：HTML全文

摘要

We investigated the action of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) in vitro on murine (3T3) and baby hamster kidney (BHK) fibroblasts and an in vivo highly metastatic subline of murine B16 melanoma (F10). CPDS determined an inhibition of cell growth and a decrease in cell adhesion, while 6-MNA had no effect. When combined with data of the mitotic index and endogenous purine ribonucleotides (on which the drugs seem to have no effect), these observations are conceivable with the hypothesis that the primary target of CPDS is cell membrane.

相关化合物

  • 6,6'-二硫二烟酸

相关文献：

Assay of biological thiols by a combination of high-performance liquid chromatography and postcolumn reaction with 6,6'-dithiodinicotinic acid.

1984-04-01

[Anal. Biochem. 138(1) , 95-8, (1984)]

Role of membrane-associated thiol groups in the functional regulation of gastric microsomal (H+ + K+)-transporting ATPase system.

1983-09-01

[Biochem. J. 213(3) , 587-94, (1983)]

The action of myocrisin on membrane bound sulphhydryl groups.

1990-12-31

[Clin. Chim. Acta 195(1-2) , 41-5, (1990)]

Activation of intestinal brush border guanylate cyclase by aromatic disulphide compounds.

1991-04-01

[Biochem. J. 275 ( Pt 1) , 29-34, (1991)]

Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species.

2011-09-01

[Toxicol. Mech. Methods 21(7) , 533-7, (2011)]

更多文献...