Synthesis and structure-activity study of protease inhibitors. V. Chemical modification of 6-amidino-2-naphthyl 4-guanidinobenzoate.
T Nakayama, S Taira, M Ikeda, H Ashizawa, M Oda, K Arakawa, S Fujii
文献索引:Chem. Pharm. Bull. 41(1) , 117-25, (1993)
全文:HTML全文
摘要
By developing 6-amidino-2-naphthyl 4-guanidinobenzoate (I, FUT-175) as a basic structure, its various derivatives were synthesized and their inhibitory activities on trypsin, plasmin, kallikrein, thrombin, C1r and C1s as well as on complement-mediated hemolysis were examined. The protective effect of these compounds on complement-mediated Forssman shock was also examined in guinea pigs. 6-Amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]-benzoate (41, FUT-187) was found to be a suitable compound for oral administration with anti-complement activity superior to that of compound I.
相关化合物
相关文献:
2015-03-21
[Org. Biomol. Chem. 13(11) , 3351-62, (2015)]
2010-07-01
[Bioorg. Med. Chem. 18(13) , 4601-5, (2010)]
2009-02-24
[Biochemistry 48(7) , 1573-83, (2009)]
1999-12-01
[Chem. Pharm. Bull. 47(12) , 1685-93, (1999)]
Doping of Polyaniline with 6-Cyano-2-naphthol. Das D, et al.
[J. Phys. Chem. B 118(45) , 12993-13001, (2014)]