Rapid access to α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones with 2-nitrophenylacetonitrile and the anti-proliferative activities of the products.
Xiaofei Zhang, Qian He, Haoyue Xiang, Shanshan Song, Zehong Miao, Chunhao Yang
文献索引:Org. Biomol. Chem. 12(2) , 355-61, (2014)
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摘要
An effective and convenient method has been developed for the preparation of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones with 2-nitrophenylacetonitrile in the presence of zinc dust, acetic acid and triethylamine. This protocol presents a simple, rapid and pot/step economical strategy for preparing biologically interesting α-carbolines with moderate anti-tumor activities.
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2002-12-11
[J. Am. Chem. Soc. 124(49) , 14546-7, (2002)]