Journal of Medicinal Chemistry 2003-09-11

The first potent and selective non-imidazole human histamine H4 receptor antagonists.

Jill A Jablonowski, Cheryl A Grice, Wenying Chai, Curt A Dvorak, Jennifer D Venable, Annette K Kwok, Kiev S Ly, Jianmei Wei, Sherry M Baker, Pragnya J Desai, Wen Jiang, Sandy J Wilson, Robin L Thurmond, Lars Karlsson, James P Edwards, Timothy W Lovenberg, Nicholas I Carruthers

文献索引：J. Med. Chem. 46 , 3957-3960, (2003)

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摘要

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.

相关化合物

  • 1-[(5-氯-1H-吲哚-2...
  • 5-甲基吲哚-2-甲酸

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