Comutagenesis-I: the in vitro metabolism of 2-amino-3-methylpyridine.
T G Altuntas, D Manson, K Zhao, J W Gorrod
文献索引:Anticancer Res. 17(5A) , 3485-91, (1997)
全文:HTML全文
摘要
The metabolism of the comutagen 2-amino-3-methylpyridine has been studied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-methylpyridine-N-oxide, 2-amino-3-hydroxymethylpyridine and 2-amino-5-hydroxy-3-methylpyridine were formed by both rat and rabbit hepatic preparations. No evidence was obtained for the formation of the corresponding 2-hydroxylamine, 2-nitroso, 2-nitro-3-methyl-pyridine or their condensation products i.e. azo, azoxy or hydrazo. The results are discussed in relation to the possible mechanism of action of the substrate.
相关化合物
相关文献:
2011-02-01
[J. Enzyme Inhib. Med. Chem. 26(1) , 104-14, (2011)]
1997-11-01
[Xenobiotica 27(11) , 1103-11, (1997)]
1997-01-01
[Anticancer Res. 17(6D) , 4479-82, (1997)]
1997-01-01
[Eur. J. Drug Metab. Pharmacokinet. 22(4) , 341-4, (1997)]