Journal of Natural Products 2009-09-01

Chemical Constituents of the Roots of Euphorbia micractina.

Wendong Xu, Chenggen Zhu, Wei Cheng, Xiaona Fan, Xiaoguang Chen, Sen Yang, Ying Guo, Fei Ye, Jiangong Shi

文献索引：J. Nat. Prod. 72 , 1620-6, (2009)

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摘要

Nine minor new tirucallane (1-7) and euphane (8 and 9) triterpenoids including five hydroperoxides, together with 18 known compounds, have been isolated from an ethanolic extract of the roots of Euphorbia micractina. Their structures including absolute configurations were elucidated by spectroscopic and chemical analysis. In the in vitro assays, betulin (10) showed a selective cytotoxic activity against A2780 ovarian cells with an IC(50) value of 6.1 microM and inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with an IC(50) value of 15.3 microM. Jolkinol B (11) showed a potent activity against HIV-1 replication with an IC(50) value of 12.6 muM. However, compounds 1-9 and the other known compounds were inactive in the three assays used.

相关化合物

  • β-谷甾醇
  • 东莨菪内酯； 莨菪...
  • 喜树碱
  • 肉桂酸
  • 白桦脂醇； 桦木醇
  • 三十烷醇
  • 齐墩果酸
  • 1-棕榈酸单甘油酯

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