Organic Letters 2006-02-02

Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions.

Jasmina Nikodinovic, Jennifer M Dinges, Stephen C Bergmeier, Mark C McMills, Dennis L Wright, Nigel D Priestley

文献索引：Org. Lett. 8(3) , 443-5, (2006)

全文：HTML全文

摘要

[reaction: see text]. An efficient resolution of methyl nonactate is reported by biotransformation in shake flask cultures of Rhodococcus erythropolis. The equilibrium of the reaction redox system can be manipulated by switching from aerobic to anaerobic growth, thereby generating both enantiomers of the target in excellent yield and enantiomeric purity.

相关化合物

  • 无活菌素来源于灰色...

相关文献：

Pilot-plant cultivation of Streptomyces griseus producing homologues of nonactin by precursor-directed biosynthesis and their identification by LC/MS-ESI.

2010-08-01

[J. Antibiot. 63(8) , 524-9, (2010)]

Synthesis of nonactin and the proposed structure of trilactone.

2006-06-22

[Org. Lett. 8(13) , 2831-4, (2006)]

Alternating pattern of stereochemistry in the nonactin macrocycle is required for antibacterial activity and efficient ion binding.

2009-12-02

[J. Am. Chem. Soc. 131(47) , 17155-65, (2009)]

Nonactin biosynthesis: the initial committed step is the condensation of acetate (malonate) and succinate.

2002-03-27

[J. Am. Chem. Soc. 124(12) , 2894-902, (2002)]

Nonactin biosynthesis: the product of the resistance gene degrades nonactin stereospecifically to form homochiral nonactate dimers.

2005-06-08

[J. Am. Chem. Soc. 127(22) , 7976-7, (2005)]

更多文献...