Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity.
Valentin Zaharia, Adriana Ignat, Nicolae Palibroda, Bathélémy Ngameni, Victor Kuete, Charles N Fokunang, Marlyse L Moungang, Bonaventure T Ngadjui
文献索引:Eur. J. Med. Chem. 45(11) , 5080-5, (2010)
全文:HTML全文
摘要
A series of novel p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles derivatives (2a-f, 3a-f and 5-8) were synthesized by initial condensation of p-toluenesulfonylthiosemicarbazide 1 with a series of α-halogenocarbonyls in acetone or dimethylformamide (DMF)/acetone, mixture. All our synthesized compounds were submitted for further acylation reaction in the presence of acetic anhydride. The structures of newly synthesized derivatives 2a-f, 3a-f and 5-8 were confirmed by IR, (1)H-NMR, EIMS spectral data and elemental analysis. Compounds 2a, 2c, 2d, 2e and 3a showed significant anticancer activities (IC(50)<10 μM) on both prostate DU-145 and hepatocarcinoma Hep-G2 cancer cell lines.Copyright © 2010 Elsevier Masson SAS. All rights reserved.
相关化合物
相关文献:
2008-08-21
[Org. Lett. 10(16) , 3461-3, (2008)]
1988-04-01
[Am. J. Physiol. 254(4 Pt 2) , F470-6, (1988)]
1992-01-01
[Toxicol. Ind. Health 8(6) , 369-76, (1992)]
2007-07-05
[Org. Lett. 9 , 2625, (2007)]
2012-01-01
[Beilstein J. Org. Chem. 8 , 2223-9, (2012)]